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-synuclein, which is a main element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) anxiety, propose that dysfunction of the intracellular proteinase devices, such as ubiquitin-proteasome technique or lysosomal system, which eliminates avoidable poisonous protein
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